As per this question and answer, it's possible to disable mouse scroll in game. However, this not only stops the camera zooming in and out, but also disables the scrolling from working in the item shop.
I currently have the opposite problem, where the mouse scroll disabled itself in game on its own and I am unable to re-enable it despite deleting the config files, restoring defaults, even repairing the client. (It's not my mouse because scrolling works everywhere else, including the lobby, etc)
Any suggestions?
11 Answer
Go to the directory/folder: C:/Riot Games/League of Legends/Config/
Open with your text editor: PersistedSettings.json
Search for: RollerButtonSpeed
You probably found something like:
{ "name": "RollerButtonSpeed", "value": "0"
}Change the value to 1.